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- ABIL: Agoraphobics Building
Independant Lives - Agoraphobia and Panic
Disorder Foundation - Anxiety Disorders Association
of America - Anxiety Network Australia
- Anxiety-Panic.Com
- AnxietyZone
- Army Behavioral Health
- BrainPhysics - OCD
- Canadian Network for Mood
and Anxiety Treatments - Children of Hoarders
- Choices in Mental Health (UK)
- Dart Foundation: Gateway to PTSD
information - David Baldwin's
Trauma Information Pages - e-couch free personal self-help guide
- EMDR Institute, Inc.
- EMDR Network Japan
- Fear of Flying course (free)
- Healthy Minds
- Information for People with Anxiety Disorders
- Internet Guide to REBT, CBT
- Knowledge Center of the
Neuroscience Initiative - Living with a Brain Disorder
- Morita Therapy
- Mayo Clinic : Depression
- Mayo Clinic : GAD
- Mayo Clinic : OCD
- Mayo Clinic : Panic Attacks
- Mayo Clinic : PTSD
- Mayo Clinic : Social Anxiety
- Medicines.org.uk - Anxiety &
Depression guides - Mind-Your-Mind Canada
- National Center for PTSD
- National Institute of Mental
Health (NIMH) - No Such Thing As Crazy
- OCD Action, UK
- OCD Ireland
- Obsessive Compulsive Foundation
- Open Minds, Open Doors
- Out of the silence - site for young people with mental illness
- Paniccure.com
- Partners With PTSD
- Prescription Drug Information
- Psychiatric Service Dog Society
- PsychNews
- Rational Emotive Behavior
Therapy (REBT) - Sane Australia
- Shyness & Social Anxiety
Service of Australia - Social Phobia/Social Anxiety
Association - Social Anxiety Support board
- South African Depression &
Anxiety Group - Suicide Prevention Help
- tAPir - the Anxiety Panic
internet resource - The Panic Center (Free
CBT based programs) - The School of OCD
- UN-WHO Drug Trials Database
- U.S. Army Behavioral Health - PTSD
we support
"just don't smoke"
Yul Brynner
- Menthol cigarettes harder to quit
- Secondhand smoke in cars serious threat to kid's health
- Lung Cancer can run in families
- Starting smoking young increases addiction risk
- Exercise helps smokers quit
- Smoking doesn't slim girls;
stunts boys' growth - Cutting down not enough, smokers must quit
- 40 reasons why you should quit smoking
- Pregnant smokers 'prime' their kids to smoke
- Smoking related coronary artery disease quickly reversed if young smokers quit
- Not ready to quit? Try cutting back
- Half smoking again within year of lung cancer surgery
- Cutting back 'compensation' increases toxin load per cigarette
- Tobacco companies upped nicotine level 11% since 1998
- Workplace passive smoke increases lung cancer risk
- Hooked by genes: The DNA sequences cigarette companies love
- Smoking causes long lasting changes to brain's bio chemistry
- Nicotine receptor stimulant trebles the odds of stopping smoking
- Bupropion, nortriptyline double chances of quitting
- Nicotine's powerful role in reinforcing smoking
- Pregnant smokers raise child's risk of stroke, heart attack
- Smoking linked to pancreatic cancer
- Neurobiology of Smokers' Cravings
- 'Low cancer risk' cigarettes as deadly as regular kind
- Quitting reduces lung cancer death risk by 70%
- Fetal nicotine exposure linked to teen attention problems
- Outdoor second-hand smoke exposure can harm
- Response to day's first cigarette predicts ease of quitting
- 'Healthy' children of smoking parents aren't really so healthy
- Children of smokers have up to five times higher levels of a nicotine toxin
- Smoking increases risk of dementia
- Smoking kills even after quitting
- Antenatal second hand smoke exposure increases child's psychological problems
- Smoking could kill 1 billion this century: WHO
- Just 1 cigarette can lead to nicotine addiction
- Smokers less likely to survive early stage lung cancer
- Smokeless tobacco delivers carcinogens more efficiently than cigarettes!
- Smoking permanently turns on genes that increase lung cancer susceptibility
- Secondhand smoke a health hazard for pets too
- Hypnosis for smoking cessation sees strong results
- Smoking doesn't burn fat
- Smoking linked to sagging breasts
- No evidence waterpipes decrease smoking harm
- Tobacco smoke + alcohol damage hearts more than either alone
What is the best strategy for antidepressant non-responders?
When your antidepressant medication does not work, should you switch to a different medication from the same class or should you try an antidepressant medication that has a different mechanism of action? This is the question asked by researchers in a new report.
Papakostas and colleagues compared two strategies for treating symptoms of major depressive disorder that do not respond to treatment with a selective serotonin reuptake inhibitor (SSRI) antidepressant: either switching to a second SSRI or to a non-SSRI antidepressant. Some common SSRI antidepressants are fluoxetine (Prozac®), citalopram (Celexa®) and sertraline (Zoloft®), while common non-SSRI antidepressants include imipramine (Tofranil®), venlafaxine (Effexor®) and buproprion (Wellbutrin®). The authors combined 4 studies comparing these two types of treatment strategies and performed a meta-analysis on the pooled data.
Dr George I. Papakostas, corresponding author for the study, explains, "Switching from a selective serotonin reuptake inhibitor to a drug with a different mechanism of action was found to be slightly more effective and slightly less-well tolerated than switching to a non-SSRI drug." Looking at the findings from a clinical perspective, the advantage in effectiveness means that 22 depressed people would need to be switched to treatment with a non-SSRI for one additional person to obtain relief from their symptoms. However, this might still be of public health benefit given the large number of SSRI-resistant patients switched to an SSRI versus a non-SSRI antidepressant.
John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, adds that this result "may be related to the fact that while somewhat different, the medications evaluated in this report all acted on the monoamine systems of the brain."
Because of the particular design of this study, the authors explain that "subsequent studies examining whether differences in efficacy between these two treatments exist for specific subpopulations, symptoms, or symptom clusters are warranted." Dr Krystal concludes that while this advantage could be important, "there continues to be a pressing need to introduce new antidepressant medications that target novel brain mechanisms."
Papakostas GI, Fava M, Thase ME. Treatment of SSRI-Resistant Depression: A Meta-Analysis Comparing Within- Versus Across-Class Switches. Biol Psychiatry 2008 Apr 1;63(7):699-704 [Abstract]