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Existence of chronic Lyme Disease disputed
There is no evidence that chronic Lyme disease exists and if it does, the risks of prolonged antibiotic treatment outweigh any benefits, according to a review article published in the October 4 New England Journal of Medicine.
Lyme disease is the most common tick-borne infection in the Northern hemisphere. The disease is caused by bacteria, Borrelia burgdorferi (also B. afzelii and B. garinii in Europe), and typically manifests as a rash, while later - less common - symptoms may include meningitis, facial nerve palsy and arthritis. All of these conditions typically respond well to conventional antibiotic treatment, but a minority of patients subsequently complain of fatigue, musculoskeletal pain, and difficulty with concentration or short-term memory. These symptoms are usually mild and self-limited and are referred to as "post-Lyme disease symptoms." If they last longer than six months, they are called "post-Lyme disease syndrome."
The review article, written by Eugene D. Shapiro, M.D., of Yale and colleagues from other institutions, focused on what the authors refer to as the "imprecisely defined" condition "chronic Lyme disease." The authors note that this term is used by a small number of physicians to describe patients they claim have persistent B. burgdorferi infection, a condition that they say requires long-term antibiotic treatment and may be incurable.
"Although 'chronic Lyme disease' clearly encompasses post-Lyme disease syndrome, it also includes a broad array of illnesses or symptom complexes for which there is no reproducible or convincing scientific evidence of any relationship to B. burgdorferi infection," said Shapiro, who is professor of pediatrics, epidemiology and public and investigative medicine at Yale School of Medicine.
The article advises clinicians to tell their patients that there is no scientific evidence of "chronic Lyme disease," and to inform patients of the risks of unnecessary antibiotic therapy. The authors say that patients should also be thoroughly evaluated for medical conditions that could explain the symptoms.
"Explaining that there is no medication, such as an antibiotic, to cure the condition is one of the most difficult aspects of caring for such patients," said Shapiro. "Failure to do so leaves the patient susceptible to those who would offer unproven and potentially dangerous therapies."
Shapiro and his colleagues maintain that "chronic Lyme disease" is a misnomer, and the use of prolonged, dangerous, and expensive antibiotic treatments is not warranted.
Feder HM Jnr, Johnson BJB, O'Connell S, et al. A Critical Appraisal of "Chronic Lyme Disease" Engl J Med 2007 Oct 4; 357:1422.[Full text]
Unfortunately, the lack of a 100% reliable test for Lyme disease complicates its recognition and treatment and may make it difficult for physicians to be certain the infective agent has been completely eliminated. However, in most cases the authors' view that 'chronic Lyme disease' is in reality a post infection syndrome is probably correct and treatment should focus on easing the symptoms instead of treating an infection that no longer exists.
In addition to the symptoms listed above, Lyme disease has been linked to a number of neuropsychiatric symptoms typical of anxiety including tingling or numbness of the fingers and toes, palpitations, disorientation, dizziness, mental 'fog,' short term memory loss, fatigue, poor concentration and sleep disturbance, and may trigger clinical depression.1 In some cases, these symptoms may not become apparent for many years after the initial infection.2
1. Kaplan RF, Jones-Woodward L, et al, (1999) "Neuropsychological Deficits in Lyme Disease Patients With and Without Other Evidence of Central Nervous System Pathology." Applied Neuropsychology, vol 6(1):p 3-11 [Abstract]
Fallon BA, Nields JA. (1994) "Lyme disease: a neuropsychiatric illness." Am J Psychiatry, vol 151(11):p 1571-83 [Abstract]
Fallon BA, Nields JA,Parsons, et al. (1993) "Psychiatric manifestations of Lyme borreliosis." J Clin Psychiatry, vol 54(7):p 263-8 [Abstract]
2. Logigian EL, Kaplan RF, et al, (1990) "Chronic neurological manifestations of Lyme disease." New England J of Medicine, vol 323:p 1438-44 [Abstract]
Went for years with undiagnosed Borrelia. Took an engorged tick into a
Texas Hospital to be told Texas didn't have Lyme Disease. This was August
of 1989. Had to stop working as an OB R.N. No tennis or jogging. Couldn't
walk much futher than my yard without great difficulty. In August of 1999
had brain aneurysm rupture and was in ICU, awakened every hr. on the hr.
However, hadn't felt so good in 10 years. They were infusing an antibiotic
called Rocephin to prevent infection. Soon after I left the hospital my
daughter called. She had to leave a medical class that morning because she
got so upset. The story being told was about a patient with vision
problems, dizzy spells, swollen joints, unexplained rashes, fast
degenerating arthritis, and tumor formations all over body, and a brain
aneuryzm rupture. The resident ordered a Borrelia test and he was positive
for Lyme Disease. This was the story my daughtered had watched with me.
She told me to ask to be tested because she remembered how upset I was the
morning her dad took the tick out of my head when she was a little girl. I
had the test and it was positive. I was given two more weeks of Rocephin
IV and I never felt better in my life. Six months later we had to move
back to Texas with the military and all the symptoms were coming back with
a new one-malaria. I saw an infectious disease doctor and he said I
couldn't possibly have malaria and I was already treated for Lyme. So I
must have Lyme Disease Syndrome. We came back to Co. and I started having
severe breathing problems. Many tests later I found my self on Oxygen
24/7. Oxygen saturation rates were very low and I had sleep apnea and
c-pap and bi-pap made the condition worse. My doctor referred me to a Lyme
Literate Clinic and I was found to be positive for two borrelia's and
babesia microti and babesia wa1. The Babesia causes a malaria type
ailment. A chest catheter was placed and I am infusing three IV's to this
day. The vision is strong, fatigue abated, fast degenerating arthritis has
stopped and I am out of the wheelchair. When I stop the antibiotics I go
back to Hell. Syphilis can be chronic, and is a much easier disease to
treat than the Borrelia's. We present the symptoms of someone with Gulf
War Syndrome, MS, ALS, Lupu, Alzheimers. I think it is probably the other
way around. The Borrelia is the cause of many of these diseases. Yale has
the patent on Borrelia, and I say shame on them for not coming forward. Do
any of the medical specialty groups think that those of us that are
fighting this disease want to spend thousands of dollars and put second and
third mortgages on our houses and spend hours a day infusing meds. for fun.
We are becomming a bigger and larger group and we are living this disease.
It is chronic. You all need to continue your studies and find out how
this disease morphs, and hides, to reappear again, to strike. If only
someone had offered me an oral antibiotic back in 1989 instead of "we don't
have Lyme Disease in Texas."
You may find this interesting Pam: Rash Judgement
Action-potential
Wave of electrochemical activity generated by the flow of positively charged ions across the neuronal membrane which causes a neuron to 'fire'- Click page link for more information -
Affective disorders
Mental disorders characterized by dramatic changes or extremes of mood - depression, mania, or both - including depression, bipolar disorder (manic depression), and schizo affective disorders.- Click page link for more information -
Alleles
An alternative form of a gene (one member of a pair) that is located at a specific position on a specific chromosome.- Click page link for more information -
Amygdalae
Two almond-shaped groups of neurons - there is one amygdala (Greek for almond) in each brain hemisphere. They have the primary role in processing and storing memories of emotional reactions.Part of the Limbic System the amygdalae trigger an instant fear reaction to perceived threats, real or imagined.
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Anterior cingulate cortex
Involved in empathy, emotions, cognitive control (attention, conflict monitoring during information processing) and plays a role in stimulus reinforcement learning and reward-guided selection of actions.Also controls autonomic functions such as heart rate and blood pressure in the context of current behavior.
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Autonomic arousal
Arousal of the autonomic nervous system which regulates many bodily functions and produces the physical symptoms of stress including the 'fight-or-flight' response.Brain-derived neurotrophic factor
Protein required for the growth and survival of nerve cells during development, and for maintenance of adult nerve cells. Studies have shown that some neurotrophic factors can trigger regrowth of damaged nerve cells and stimulate growth and differentiation of new neurons in the hippocampus (neurogenesis).- Click page link for more information -
Client-centered therapy
An approach to counseling and psychotherapy that places much of the responsibility for the treatment process on the client, with the therapist taking a non-directive role. Also called non-directive, person-centered, or Rogerian therapy.- Click page link for more information -
Cognitive-behavior therapy (CBT)
Type of psychotherapy emphasizing the important role of thinking in how we feel and what we do.Based on the concept that our thoughts cause our feelings and behaviors, not external things like people, situations, and events. The benefit of this fact is that we can change the way we think to feel/act better even if the situation does not change.
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(Additional information in Ai side panel)
Clinical trial-Phase 1
The first test in humans of a new treatment to see if it is safe to use in people.- Click page link for more information -
Compassion meditation
Based on Tibetan Buddhism techniques. Trains the mind to optimize the way it perceives relationships with others. Experienced practitioners are able to alter brain functioning to boost positive emotions, and enhance their immune systems.Related to Mindfulness Meditation/Psychotherapy.
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Corticotropin-releasing factor
A polypeptide hormone and neuro- transmitter involved in the stress response.CRF hyper secretion is believed to contribute to hyperactivity of the hypothalamic-pituitary-adrenal axis in depressed patients. Hyper secretion has also been implicated in anxiety.
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Cortisol
The most potent of the stress hormones. Synthesized from cholesterol by the adrenal glands. Increases blood pressure, blood sugar levels and suppresses immune function.- Click page link for more information -
Cross sectional study
Epidemiological studies describing population characteristics which collect data at one point in time and then consider relationships between observed characteristics.. Because they don't look at time trends they cannot establish causes.
Cytochrome P450
Family of enzymes involved in the metabolic process. P450 liver enzymes metabolize most prescribed pharmaceutical and alternative medications.- Click page link for more information -
Cytokines
A diverse group of signaling (messenger) molecules that mediate both the innate and adaptive immune response by regulating immunity, inflammation, and hematopoiesis (blood cell development).Cytokines include the Interleukins, Interferons, Tumor Necrosis Factor Alpha and Transforming Growth Factor beta.
Cytokines are increasingly being used to treat cancers and viral infection, however, depression onset is a common side effect.
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Dentate gyrus
Part of the hippocampus. Thought to contribute to formation of new memories and is one of the few brain regions where neurogenesis occurs. Has a role in recognizing the differences that make each place unique. Processing errors may play a role in deja vu.- Click page link for more information -
Depression - Atypical
Defined by the ability to feel better temporarily in response to positive life events, plus any two of the following criteria: excessive sleep, overeating, a feeling of heaviness in the limbs and a sensitivity to rejection. Despite the name, it is actually the most common form of depression.- Click page link for more information -
Depression - Clinical/Major
Characterized by a pervasive, unremitting low mood and loss of interest or pleasure in usual activities. In addition there are other physical and mental symptoms that may include fatigue, difficulty with concentration and memory, feelings of hopelessness and helplessness, headaches, body aches, and thoughts of suicide.- Click page link for more information -
Dysthymia
Mood disorder within the depression spectrum. Considered a chronic depression, but less severe than major depression.- Click page link for more information -
Emotion focussed therapy
A short term (8-20 session) psychotherapy based on helping the patient express emotions more easily and thus release unprocessed feelings and thoughts so that they may be dealt with openly.- Click page link for more information -
Epigenetic inheritance
Process by which environmental factors like diet, stress, and ante/post-natal maternal factors can change gene function without altering the DNA sequence. These changes may remain through cell divisions and may also be passed down through multiple generations.- Click page link for more information -
Fear extinction
Suppression of the expression of previously learned fear by repeated exposure to the object of fear without negative consequences. Also called 'inhibitory learning'- Click page link for more information (
) -First-degree relative
A parent, sibling or child of an individual.Gamma-Aminobutyric Acid (GABA)
The major inhibitory neurotransmitter of the central nervous system. Dampens brain activity and promotes a state of calm.An amino acid produced in the brain as a by-product of the Krebs glucose metabolism cycle which powers brain cells.
Note 1: Benzodiazepines (Valium® etc) do not increase brain GABA levels, but increase the sensitivity of GABA receptors.
Note 2: GABA does not normally penetrate the Brain-Blood-Barrier (the BBB tends to pull GABA from the brain into the blood stream (Kakee A, 2001)) so GABA supplements are, at best, expensive placebos.
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Glial Cells
Support cells in the brain and spinal cord which provide physical and nutritional support for neurons, form the blood-brain barrier, clear dead cells and other debris, insulate neurons and, as part of the immune system, protect the brain from microorganisms.Long thought not to conduct electrical impulses as the neurons do, there is growing evidence that they do modulate neurotransmission.
The largest group of cells of the central nervous system being between 50-100 times more abundant than neurons.
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Haplotype
A group of alleles of different genes on a single chromosome that are so closely linked that they are usually inherited as a unit.- Click page link for more information -
Heterozygote, Homozygote
Heterozygote: Any organism which has two differing forms of a particular gene for a specific trait, one inherited from each parent.Homozygote: Any organism which has two identical forms of a particular gene for a specific trait, one inherited from each parent.
Because genes are either dominant or recessive, the genetic makeup (genotype) of an organism cannot always be determined by physical appearance alone.
Hippocampus
A seahorse shaped sheet of neurons laying next to the Amygdalae. Regulates emotions and short term memory.- Click page link for more information -
Homologous
Anatomical structures that perform the same function in different biological species having evolved from the same structure in a shared ancestor species.Hypothalamus
Regulates homeostasis, the maintenance of the body's status quo by producing hormones which control: Body temperature, Hunger, Moods, Sex drive, Sleep and Thirst.- Click page link for more information -
Hypothalamic-pituitary-adrenal axis
A major part of the neuroendocrine system, comprising of the hypothalamus, pituitary gland and the adrenal glands, which controls reactions to stress and regulates many body processes, including digestion, the immune system, mood and emotions, sexuality, and energy storage and expenditure.- Click page link for more information -
Interleukins - (IL-1 - IL-35)
Signaling molecules critical to the functioning of the immune system.A recombinant form of IL-2 has been approved as an anti cancer drug and and may have anti viral properties. Changes in mental states including irritability, confusion, or depression are a known side-effect.
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Interpersonal psychotherapy
Time-limited psychotherapy focusing on the interpersonal context and building interpersonal skills. Based on the belief that interpersonal factors may contribute heavily to psychological problems. Distinguished from other forms of therapy in its emphasis on the interpersonal rather than the intra psychic.- Click page link for more information -
in vitro - in vivo
in vitro (Latin: within the glass) Experiments conducted with parts of an organism (often only a few cells) in a test-tube, petri dish, etc.in vivo (Latin: within the living) Experiments conducted with more or less whole organisms.
Ion channel (ionopore)
Pore-forming proteins in cell walls which allow the movement of electrically charged ions across cell membranes that produce the electrical gradients responsible for nerve impulses.- Click page link for more information -
Learned helplessness
A psychological state in which people gradually come to feel that they have no control over repeated adverse events and that failure is inevitable so become less willing to attempt tasks. A coping mechanism for surviving difficult or abusive circumstances. It offers a model to explain human depression, in which apathy and submission prevail.- Click page link for more information -
Limbic system
Brain structure of the 'old' mammalian brain comprising the hippocampus, amygdalae, anterior thalamic nuclei, and the diencephalon in the forebrain. Regulates memory, and the emotions including fear, anger, and of sexual behavior.- Click page link for more information -
Ligand
A molecule that is able to bind to and form a complex with a biomolecule to serve a biological purpose. Neurotransmitters are one type of ligand.Longitudinal study
Research which studies a group of people over a period of time.Lyme disease
Caused by spirochaete bacteria of the genus Borrelia which are found worldwide. It is called 'Chronic lymphocytic meningitis', 'Neuroborreliosis', 'Garin-Bujadoux syndrome' and 'Bannwarth's syndrome' in Europe.In addition to symptoms typical of infectious disease - fever, chills, headache, rash etc, Lyme can also produce 'classic' anxiety symptoms including tingling or numbness of the extremities, disorientation, mental 'fog,' short term memory loss, fatigue, poor concentration and sleep disturbance, and may trigger depression. In some cases, these symptoms may not become apparent for many years after the initial infection.
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Meta-analysis
Mathematical technique to amalgamating, summarizing, and reviewing previous quantitative research to arrive at one overall measure of treatment effect.A weakness of the method is that sources of bias in the original research are not controlled by the method. A good meta-analysis of badly designed studies will still result in bad statistics.
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Mindfulness
"Mindfulness is not a quick fix. The mindful approach encourages the person suffering from anxiety to move in close to their uncomfortable feelings, to watch the feelings of panic and racing heart, trembling hands, etc., with curiosity, openness and acceptance because, in fact, they are already there. This is a practice. We begin to become more tolerant of so-called negative states of mind, and then comfortable with them, then aware that everything changes constantly, including these states of mind. We begin to see anxiety for what it is: our body's adaptation to stress or to a thought and its subsequent attempt at communicating it to us."Barbara Wilkinson,
certified trauma therapist
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Mindfulness meditation/ psychotherapy
Mindfulness is the practice of becoming more aware of the present moment, rather than dwelling in the past or projecting into the future. It generally involves a heightened awareness of sensory stimuli (really noticing your breathing, feeling the sensations of your body, etc); and being 'in the now'. Principles may be combined with the concepts of Cognitive-Behavior Therapy (CBT) as Mindfulness-based Psychotherapy.- Click page link for more information -
Narrative Exposure Therapy
Therapy developed to treat PTSD. Based on cognitive behavioral exposure therapy, it adapts classical exposure therapy to meet needs of traumatized survivors of war and torture.Survivors are asked to describe what happened to them in great detail, focusing on what they saw, heard, smelt, etc, and their feelings and thoughts at the time. Initially, sessions are distressing, but as they are long enough to allow habituation, distress levels diminish towards the end and more and more details are recalled.
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Neurogenesis
Process by which new neurons are generated after the postnatal stage of development. It appears to only occur in two areas of the brain, the hippocampus and the olfactory bulbs. Hippocampal neurogenesis is thought to counter anxiety and depression.- Click page link for more information -
Neuropeptide
One of about 100 peptides including endorphins, enkephalins, oxytocin and vasopressin which mediate brain function by regulating gene expression, local blood flow and synaptogenesis. The neuropeptides Cholecystokinin, Substance P and Neuropeptide Y have been linked to anxiety and depressive disorders.- Click page link for more information -
Neuroplastic
The brain's ability to reorganize itself by forming new neural connections.- Click page link for more information -
Nucleus accumbens
Twin brain structures (one in each hemisphere) involved in reward, laughter, pleasure, addiction, fear, and the placebo effect.- Click page link for more information -
Polymorphism
Natural variations in a gene, DNA sequence, protein, or chromosome.-Click page link for more information-
Prefrontal Cortex
Area of the brain's frontal lobes involved in planning complex cognitive behaviors, the expression of personality and social behavior.- Click page link for more information -
Prospective study
Tests a specific question, usually about how a specific exposure(s) affects a specific outcome(s) by recruiting appropriate participants and checks the outcomes over the following months or years.Psychodynamic psychotherapy
Talking therapy used to help a person find relief from emotional pain. It is based on the theories and techniques of Freudian/Jung style psychoanalysis. However, practitioners don't necessarily accept the 'classical' psychoanalysis theory that emotional conflicts are primarily sexual in nature.Receptor
Short-lived protein molecules embedded in the cell wall of neurons, especially of their synapses, to which neurotransmitters attach to initiate an action. Also called ´binding sites´- Click page link for more information -
Receptor agonist
A chemical which is able to bind to receptors of a neurotransmitter and trigger the same biological response as that neurotransmitter.Receptor antagonist
A drug that is so similar chemically to a neurotransmitter that it is capable of binding to a receptor for the neurotransmitter but which does not trigger the biological response of that neurotransmitter. By blocking its receptors the antagonist disrupts or inhibits the action of the neurotransmitter.Retrospective study
Research using data on exposures and/or outcomes that have already been collected through medical records or as part of another study. Such data may not be as reliable as data collected prospectively, as it relies on the accuracy of records made at the time, and on people’s recall of past events, which can be inaccurate (referred to as recall bias).Safety behavior
Behavior undertaken to reduce anxious thoughts, or to keep yourself 'safe' from imagined threats, or to hide your anxious state from others. Examples include constant monitoring of breathing or heart rate, shopping during quiet retail hours, taking precautionary tranquillizers "just in case," taking circuitous routes to avoid highways or bridges when driving, sitting close to exits, avoiding eye contact, playing with keys to hide trembling hands.Seasonal affective disorder
A type of depression triggered by the seasons. The most common type is winter-onset depression (aka Winter blues), but some also regularly become depressed at the start of spring-summer.- Click page link for more information -
Serotonin syndrome
A potentially life-threatening adverse reaction triggered by excess serotonergic activity in the central nervous system.- Click page link for more information -
Serotonin transporter
A protein that transports the neurotransmitter serotonin across cell membranes.- Click page link for more information -
Significant life events
Major stressors such as: death of relative (incl. miscarriage), friend, or pet; serious illness or injury, surviving a disaster; marriage, separation, divorce, relationship breakup; birth or adoption of a child; moving house or school; new job or promotion, unemployment or retirement;Somatization disorder
Manifests as chronic, persistent complaints of varied physical symptoms that have no identifiable organic origin or basis. Often co morbid with other psychological disorders, particularly anxiety or mood disorders, plus irritable bowel syndrome and chronic pain. Occurs in 0.2% to 2% of females and 0.2% of males. Also known as Briquet's disorder.Sympathetic nervous system
The part of the nervous system which controls the body’s internal, involuntary processes including breathing, digestion, blood vessel tone, heart rate, etc. It also mediates the fight-or-flight response.Subgenual cingulate
Brain region high in serotonin transporter-binding sites, with strong projections to the hypothalamus and brain stem. Modulates autonomic/neuroendocrine responses and neurotransmitter transmission during the neural processing of reward, fear, and stress. May be critical for modulating widespread behavioral changes mediated by the cortex. Volume is often decreased in mood disorders patients.Also known as Brodmann area 25.
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Synapses
Gaps between neurons through which "information" flows from one neuron (brain cell) to another.- Click page link for more information -
Thalamus
Regulates sleep and awake states, arousal and awareness. Processes and relays sensory information to the cerebral cortex where they are experienced as sensations of pain, touch, or temperature. Damage to the thalamus can produce permanent coma.- Click page link for more information -
Tumor necrosis factor-α
A cytokine which has wide range of pro inflammatory actions and induce necrosis (death) of tumor cells. Exacerbates chronic inflammatory autoimmune diseases such as rheumatoid arthritis.Blood plasma levels are raised in patients with depression. Research had shown that antidepressants reduce its expression.
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White matter
Regions of the brain and spinal cord largely composed of nerve fibers (axons) sheathed in insulating myelin composed of lipids (fats) which give them their color.White matter abnormalities (hyperintensities):
Damage to the myelin insulation. May be inherited, the result of disease (Multiple Sclerosis) or physical injury, stroke etc. Most brains accumulate some WM abnormalities with age.
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